Anastrozole: Uses, Interactions, Mechanism of Action DrugBank Online
Anastrozole doesn’t work well in women with estrogen receptor-negative breast cancer. It also doesn’t work well in women whose bodies didn’t respond to treatment with tamoxifen. Vaginal dryness and related painful intercourse is one of the more common side effects of cancer therapy in women. Vaginal lubricants and moisturizers (longer-lasting forms of moisturizers) can help with these concerns. Talk to your healthcare team for more suggestions in managing this side effect.
- (Arimidex is considered a hormone therapy.) But keep in mind that this is an off-label use of the drug.
- On average, 40% of the patients had soft tissue metastases; 60% had bone metastases; and 40% had visceral (15% liver) metastases.
- Your doctor will check to see if your breast cancer growth has decreased or stopped by doing a breast exam.
- But to know for sure how long you should take Arimidex, talk with your doctor.
- For all doses, anastrozole did not affect cortisol or aldosterone secretion at baseline or in response to ACTH.
You may be more likely to have a broken bone while using anastrozole. Talk with your doctor about ways to keep your bones healthy. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Anastrozole oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works.
Adverse Reactions/Side Effects
When you stop taking Arimidex, the drug that’s left in your body will be gradually broken down by your liver. How long Arimidex stays in your system can vary from person to person. But most of the drug is usually removed from your body within about 10 days. These lists contain examples of serious side effects that can occur with Arimidex, with letrozole, or with both drugs (when taken individually). These lists contain examples of mild side effects that can occur with Arimidex, with letrozole, or with both drugs (when taken individually). Letrozole is an active drug that’s available in both generic and brand-name forms.
For all doses, anastrozole did not affect cortisol or aldosterone secretion at baseline or in response to ACTH. No glucocorticoid or mineralocorticoid replacement therapy is necessary with anastrozole. Patients receiving Anastrozole had a higher incidence of carpal tunnel syndrome [78 (2.5%)] compared with patients receiving tamoxifen [22 (0.7%)]. Estrogens are steroid hormones that come in three forms, estrone (E1), estradiol (E2) and estriol (E3). Estrogens are essential for normal sexual development and function, and in addition, have many other important functions in the body.
What should I do if I forget a dose?
- Arimidex is meant to be used as a long-term treatment for breast cancer.
- Adverse reactions occurring with an incidence of at least 5% in either treatment group during treatment or within 14 days of the end of treatment are presented in Table 1.
- Increases in LDL cholesterol have been shown to contribute to these changes.
- Other interactions can increase side effects or make them more severe.
You can also ask your pharmacist for information on how to dispose of your medication. When you get Arimidex from the pharmacy, the pharmacist will add an expiration date to the label on the bottle. This date is typically 1 year from the date they dispensed the medication. Because of this interaction, you shouldn’t take tamoxifen with Arimidex. However, if recommended by your doctor, it’s fine to take Arimidex after you’ve finished taking tamoxifen.
Monotherapy with CC, however, may result in increased levels of E2 and eventual disruption of the T/E2 ratio, negatively affecting spermatogenesis . Treatment with an aromatase inhibitor (AI) such as https://www.pitstopautostore.it/2023/09/15/new-meltos-40-mcg-steroid-course-shows-promising/ may improve the decreased T/E2 ratio and also improve sperm parameters . Anastrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body. Some women report mood swings and depression while on hormone therapy.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. Anastrozole is a medication that treats breast cancer among people who have gone through menopause. This can stop tumor growth because some types of breast cancer need estrogen to grow. Find Clinical Trials for Anastrozole – Check for trials from NCI’s list of cancer clinical trials now accepting patients.
4 Bone Effects
Take this medication by mouth with or without food as directed by your doctor, usually once a day. Your doctor may order certain lab tests to check your body’s response to anastrozole. Call your doctor if you have any unusual problems while taking this medication. You may need to take anastrozole for several years or longer. Do not stop taking anastrozole without talking to your doctor.
In this trial, treatment for 12 months with ARIMIDEX alone had a neutral effect on lipid profile. Combination treatment with ARIMIDEX and risedronate also had a neutral effect on lipid profile. In both populations for lipids, there was no clinically significant difference in total cholesterol (TC) or serum triglycerides (TG) at 12 months compared with baseline. Adverse reactions occurring with an incidence of at least 5% in either treatment group during treatment or within 14 days of the end of treatment are presented in Table 1. No dosage adjustment is necessary for patients with renal impairment or for elderly patients [see Use In Specific Populations]. It should not be administered to nursing mothers to avoid any harm to the newborn.